Fibrosis & Immunology
Any non-self surface activates the first response of the immune system, the innate immune cascade complement. This leads to cell activation that can culminate in a fibrosis response to enclose biomaterials resulting in the failure of the intended applications. We will engage at different levels of these processes to define the underlying bio-responses at a molecular level. Consequently, we will generate tailor-made applications to overcome these detrimental, unwanted body responses to stir the function and lifetime of modern biomaterials.
Publications
Saleem, S. K.; Decker, S.; Kissel, S.; Bauer, M.; Chernyakov, D.; Brauer-Hartmann, D.; Aumann, K.; Wickenhauser, C.; Herling, M.; Skorobohatko, O.; Mathew, N.; Schmidt, C.; Klein, C.; Follo, M.; Dierks, C. JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL. J Exp Med 2025, 222 (1). DOI: https://doi.org/10.1084/jem.2023068
Winterhalter, P. R.; Simm, A. Beneficial death: A substantial element of evolution? Biogerontology 2025, 26 (1), 39. DOI: 10.1007/s10522-024-10176-w
Braun, G.; Herberth, G.; Krauss, M.; Konig, M.; Wojtysiak, N.; Zenclussen, A. C.; Escher, B. I. Neurotoxic mixture effects of chemicals extracted from blood of pregnant women. Science 2024, 386 (6719), 301-309. DOI: 10.1126/science.adq0336
Gellert, P.; Brandenburg, H.; Franke, A.; Kessler, E. M.; Krupp, S.; Pantel, J.; Schramek, R.; Simm, A.; Swoboda, W.; Wurm, S.; et al. Strengthening prevention and health promotion in and for old age. Z Gerontol Geriatr 2024, 57 (3), 199-206. DOI: 10.1007/s00391-023-02262-4
Fischer, F.; Kretschmer, T.; Seifert, P.; Howanski, J.; Krieger, E.; Rodiger, J.; Fink, B.; Yin, Z.; Bauer, M.; Zenclussen, M. L., Meyer, N., Schumacher, A., Zenclussen, A.C. Single and combined exposures to bisphenol A and benzophenone-3 during early mouse pregnancy have differential effects on fetal and placental development. Sci Total Environ 2024, 922, 171386. DOI: 10.1016/j.scitotenv.2024.171386
Grosskopf, A.; Rahn, J.; Kim, A.; Szabo, G.; Rujescu, D.; Klawonn, F.; Frolov, A.; Simm, A. Peptide-Bound Glycative, AGE and Oxidative Modifications as Biomarkers for the Diagnosis of Alzheimer’s Disease-A Feasibility Study. Biomedicines 2024, 12 (9). DOI: 10.3390/biomedicines12092127
Kendzia, S.; et int; Kessler, S. M. A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer. Mol Cancer 2023 22:89, https://doi.org/10.1186/s12943-023-01787-x
Czepukojc, B.; Barghash, A.; Tierling, S.; Simon, Y.; Körbel, C.; Cadenas, C.; van Hul, N.; Sachinidis, A.; Hengstler, J.G.; Helms, V.; Laschke, M.W.; Walter, J.; Haybaeck, J.; Leclercq, I.; Kiemer, A.K.; Kessler, S.M. IGF2 mRNABinding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis. Front Med 2019 6, 179, https://doi.org/10.3389/fmed.2019.00179
Collaborative research centers / Network
