Tooth materials

Dental diseases like caries and periodontitis are widespread and promote the occurrence of other diseases. We study new approaches towards tooth and periodontal regeneration via chemical materials synthesis, novel clinical applications and material combinations towards a patient- and problem-specific repair and restoration, including sustainable, self-repairing, and biobased approaches. Novel materials and application technologies bridges basic material with applied clinical methodologies.

Prof. Dr. Kerstin Bitter

Prof. Dr. Andreas Taubert

Prof. Dr. Erica Lilleodden

Prof. Dr. Olga Polydorou

Publications

Bai, S., Rau, S.J., Steinberg, T., Tomakidi, P., Polydorou, O. A Dusty Affair: SIRT1-S682 Modulation Orchestrates ERK FN1–p38–NF-κB Signaling and Composite-Dependent IL-8 Responses in Gingival Keratinocytes Exposed to Dental Dust and Eluates. Journal of functional Biomaterials, 2026, 17,264 https://doi.org/10.3390/jfb17060264

Reidelbach, C., Raab, L., Hellwig, E., Vach, K., Garcia-Käufer, M., Polydorou, O. Ecotoxic and genotoxic potential of eluates from dental composite dust – an in vitro study. Dental Materials, 2026 DOI:10.1016/j.dental.2026.04.017.

Schulz, S.; Reuter, L.; Navarrete Santos, A.; Bitter, K.; Rehm, S.; Schlitt, A.; Reichert, S. Major Adverse Cardiovascular Events: The Importance of Serum Levels and Haplotypes of the Anti-Inflammatory Cytokine Interleukin 10. Biomolecules 2024, 14 (8). DOI: 10.3390/biom14080979

Kleinvogel, L.; Wemken, G.; Reidelbach, C.; Garcia-Kaufer, M.; Vach, K.; Hellwig, E.; Spies, B. C.; Polydorou, O. Method development for the intraoral release of nanoparticles from dental restorative materials. Dent Mater 2023, 39 (8), 693. DOI: https://doi.org/10.1016/j.dental.2023.06.006

Himmelsbach, S.; Steinberg, T.; Tomakidi, P.; Garcia-Kaufer, M.; Hellwig, E.; Polydorou, O. Effect of dental composite dust on human gingival keratinocytes. Dent Mater 2023, 39 (11), 994-1003. DOI: https://doi.org/10.1016/j.dental.2023.09.00

Bitter, K., Fleck, C., Lagrange, A., Rack, A., Zaslansky, P.: Time-lapse submicron particle motion reveals residual strain evolution and damaging stress relaxation in clinical resin composites sealing human root canals. Acta Biomater. 2022 Mar 1;140:350-363. https://doi.org/10.1016/j.actbio.2021.10.052

Mai, T.; Wolski, K.; Puciul-Malinowska, A.; Kopyshev, A.; Gräf, R.; Bruns, M.; Zapotoczny, S.; Taubert, A. Anionic polymer brushes for biomimetic calcium phosphate mineralization—a surface with application potential in biomaterials. Polymers, 2018, 10 (10), 1165. https ://doi.org/10.3390/polym10101165

Schneider, M.; Günter, C.; Taubert, A. Co-deposition of a hydrogel/calcium phosphate hybrid layer on 3D printed poly (lactic acid) scaffolds via dip coating: Towards automated biomaterials fabrication. Polymers, 2018, 10 (3), 275. https://doi.org/10.3390/polym10030275